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KMID : 0191120230380010003
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Journal of Korean Medical Science
2023 Volume.38 No. 1 p.3 ~ p.3
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Risk of Rapid Lung Function Decline in Young Adults With Chronic Obstructive Pulmonary Disease: A Community-Based Prospective Cohort Study
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Kim Sang-Hyuk
Lee Hyun
Joo Hyon-Soo
Choi Ha-Young
Sim Yun-Su
Rhee Chin-Kook
Park Yong-Bum
Kim You-Lim
Yoo Kwang-Ha
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Abstract
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It is unclear whether young adults with chronic obstructive pulmonary disease (COPD) are at an increased risk of rapid lung function decline. A total of 2,934 Korean adults aged 40?49 years who had consecutive lung function measurements were included. COPD was defined as pre-bronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity < lower limit of normal. The risk of rapid decline in FEV1, defined as ≥ 60 mL/year, was assessed using multivariable logistic regression analysis. In the multivariable model, a significantly higher risk of rapid decline in FEV1 was observed for the COPD group compared with the non-COPD group (adjusted odds ratio, 1.89; 95% confidence interval, 1.18?2.95), which was especially significant in subjects with FEV1 less than the median value (< 110%pred) (Pinteraction = 0.017) and inactive physical activity (Pinteraction = 0.039). In conclusion, the risk of rapid FEV1 decline was higher in young adults with COPD than in those without COPD, especially in those with FEV1 less than the median value and inactive physical activity.
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KEYWORD
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Lung Diseases, Obstructive, Pulmonary Disease, Chronic Obstructive, Respiratory Function Tests, Spirometry, Young Adult, Preventive Health Services
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